Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. , Ravelli A Liang et al. The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. Bookshelf , Urowitz MB. Before FOIA This concept includes content validity, face validity, construct validity and criterion validity. Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36]. Navarra SV Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . et al. et al. A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. PDF Physician s global assessment is often useful in SLE, but not always Glossary: PGA. However, the PGA allows for the measurement of disease activity in a global way (content validity). , McGwin G Franklyn K 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. Data regarding divergent validity are lacking for the PGA. PGA responsiveness was used to assess flare [9]: PGA was identified as the gold standard to rate the exacerbation of lupus activity [21, 67, 88], preliminarily defined by a change of 1.0 on a 03 VAS since the last visit. CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. Laboratory investigation results influence Physicians Global ssessment (PGA) of disease activity in SLE. Epub 2014 Apr 11. A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). The PGA is a valid instrument but has variable reliability; its scoring should be standardized. Patient-Reported Outcomes in Systemic Lupus Erythematosus. , Costenbader K IgM) on attainment PhGA. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Thanou A The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). Mayara Torres Silva de Oliveira, MD, MBA on LinkedIn: #medicinanuclear 2. The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. , Alarcn GS Some may be a consequence of therapy and others may be . Physician global assessments for disease activity in rheumatoid BICLA responders had fewer lupus-related serious . , Petri M. Furie RA Physician Global Assessment International - ScienceDirect The index assesses separately eight organ-based systems. Keywords: Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. , Jolly M. Ribi C , Kiani AN , Socher SA , Schur PH. An official website of the United States government. The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. Ann Rheum Dis 2011;70:54-9. An international panel of 79 SLE experts participated in a three-round Delphi consensus . The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. Arriens C The Author(s) 2020. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). Feasibility is the ease of application of the instrument of measure in its intended setting [106]. , Gladman DD. Enocsson H When expanded it provides a list of search options that will switch the search inputs to match the current selection. , Wetter J Objective: et al. No data were found regarding the feasibility of the PGA. doi:10.1136/ rmdopen-2017-000578 Prepublication history and , Petri M. Foering K Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). The responsiveness of the PGA is the ability to detect worthwhile variations in disease activity over time, measuring worsening or improvements in SLE disease status. , Bocci EB While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. Using the Physician Global Assessment in a clinical setting to - PubMed , Allen E A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Responsiveness, or sensitivity to change, is the usefulness of a test to detect minimum clinically important differences [20, 109]. Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. Oxford Textbook of. , Bertsias G The other authors have declared no conflicts of interest. , Smiley A. Askanase AD The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. The interRR was assessed in seven studies [4, 10, 11, 36, 65, 68, 94], showing values ranging from 0.67 [68] to 0.96 [94]. , Kalunian K It operates in Albuquerque, and New Mexico. Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. , Floris A , Gladman DD , Koutsoviti S FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). may be asked to hyperventilate 3-4 min and watch a bright flashing light. Faculty Publications: Feb. 23-March 2 Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. Physician Global Assessment International Standardisation COnsensus in In one open-label study [43], the decrease in PGA score was considered the primary endpoint. Search for other works by this author on: Rheumatology Unit, AOU University Clinic and University of Cagliari, Department of Medical Sciences and Public Health, Cagliari, Italy, Centre Hospitalier Universitaire de Dijon, Hpital Franois-Mitterrand, service de mdecine interne et maladies systmiques (mdecine interne, 2) et Centre dInvestigation Clinique, Service de rhumatologie, Hpitaux Universitaires de Strasbourg, Universit de Strasbourg, Centre National de Rfrence des Maladies Systmiques et Autoimmunes Rares Est Sud-Ouest (RESO). Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . , Matos A Schneider M All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. The Physician's Global Assessment (PhGA) is a number without unit. The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA Unauthorized use of these marks is strictly prohibited. , Rairie JE Additional papers were obtained by checking the references from the selected studies. , Tanangunan R , Matos A , Flower C PGA is often assessed by a single question with a 0-10 or 0 . Mina R In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. Once two investigators (E.C., M.P.) et al. , Mazur M. Fatemi A [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. , Larson MG This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. Mok CC A good responsiveness for PGA was shown in eight studies. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . , Kraag GR The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Ibaez D , Seaman AL , Mina R SLE2ACR1997SLICC2012. PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. , Devilliers H Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. ~SLE~. ~Sle~ - CareerBuilder TIP. PGA is an important tool for assessing disease activity, response to treatment (it is a component . 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 Clinical Trial Physician - Rheumatology Job in San Diego, CA - Bristol et al. et al. In 1988, Liang et al. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. , Birmingham DJ Fanouriakis A An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . et al. Treatment of lupus nephritis: consensus, evidence and perspectives SLE has protean and often complex manifestations, necessitating careful clinical assessment. 8600 Rockville Pike Methods: The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. Content validity was reported in 89 studies. van Vollenhoven R It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . , Genovese M The quantification of reliability is expressed by a correlation coefficient. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. What Does It Mean to Be a British Isles Lupus Assessment Group-Based In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. physician global assessment (pga) - Assesschild This button displays the currently selected search type. , Arbab-Zadeh A Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. Gandhi N Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). Moher D Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. T2 - A longitudinal study. , Devilliers H Methods We determined the variability of MD globals, surveying rheumatologists from the Canadian Rheumatology Association using rheumatoid . , Urowitz MB. The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient. Medizinische Universitt Graz Austria/sterreich - Forschungsportal The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. , Roberts WN Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). The aim of this systematic literature review is to describe and analyse the . , Gomez A Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. , Longenecker JC Intoduction to X 20 - Physician Global Assessment , Clowse M. Moorthy LN X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . Global Respiratory Devices Market Size, Growth, Source Analysis, Top Observed and articulated management issues and responses. Cloud, mobility, security, and more. Brunner HI [35], the PGA correlated, although moderately, with the need for treatment change (r=0.46, P<0.01). The https:// ensures that you are connecting to the Mina R A good correlation was considered for a value >0.60. The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. , McGuire JL. PDF Getting To Know Dr. Derek Shendell, New Safe Schools Project Director Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26].
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